I-A09 and its derivatives, specifically 1,2,3-triazole-adamantylacetamide hybrids (5a-u), exhibit significant antitubercular activity. These hybrids were synthesized using copper-catalyzed click chemistry, combining bioactive fragments from antitubercular I-A09 and substituted adamantyl urea. The compound N-(1-adamantyl)-2-azido acetamide was reacted with various alkyl/aryl acetylenes to produce new analogues. Among them, N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t) showed the most promise with a minimum inhibitory concentration (MIC) of 3.12 µg/mL against Mycobacterium tuberculosis H37Rv, and a selectivity index greater than 15[1].
Molekulargewicht:
539.54
CAS Nummer:
[1143579-76-3]
Formel:
C29H25N5O6
Target-Kategorie:
Bacterial
Anwendungsbeschreibung:
MCE Product type: Reference compound
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