NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1beta[1].
Molekulargewicht:
418.24
Reinheit:
98.72
CAS Nummer:
[2806031-94-5]
Formel:
C21H25BF2N2O4
Target-Kategorie:
NOD-like Receptor (NLR),Proteasome
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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