JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia[1].
Molekulargewicht:
325.15
Reinheit:
99.55
CAS Nummer:
[2242031-31-6]
Formel:
C13H10Cl2N4O2
Target-Kategorie:
Apoptosis,JAK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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