ONT-093 (OC 144-093) is a potent and orally active inhibitor of P-glycoprotein pump. ONT-093 inhibits P-gp-mediated ATPase activity with an IC50 of 0.16 µM. ONT-093 can inhibit drug efflux and increase bioavailability. ONT-093 reverses cancer cells multidrug resistance to chemotherapeutic drugs. ONT-093 can be used for the researches of cancer and infection, such as colon cancer and malarial [1][2][3].
Molekulargewicht:
494.67
Reinheit:
99.21
CAS Nummer:
[216227-54-2]
Formel:
C32H38N4O
Target-Kategorie:
P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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