P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner[1].
Molekulargewicht:
393.40
Reinheit:
98.62
CAS Nummer:
[2765180-17-2]
Formel:
C19H19N7O3
Target-Kategorie:
Apoptosis,E1/E2/E3 Enzyme,p62
Anwendungsbeschreibung:
MCE Product type: Reference compound
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