Avosentan (Ro 67-0565, SPP-301) is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure[1][2][3][4].
Molekulargewicht:
479.51
Reinheit:
98.15
CAS Nummer:
[290815-26-8]
Formel:
C23H21N5O5S
Target-Kategorie:
Endothelin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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