Menin-MLL inhibitor MI-2 is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL)[1].
Molekulargewicht:
375.55
Reinheit:
99.81
CAS Nummer:
[1271738-62-5]
Formel:
C18H25N5S2
Target-Kategorie:
Apoptosis,Epigenetic Reader Domain
Anwendungsbeschreibung:
MCE Product type: Reference compound
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