BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 µM. BDM-2 exhibits highly selective and favorable cytotoxicity[1].
Molekulargewicht:
394.50
Reinheit:
99.09
CAS Nummer:
[1643876-33-8]
Formel:
C25H30O4
Target-Kategorie:
HIV,HIV Integrase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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