RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 µM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1].
Molekulargewicht:
361.61
Reinheit:
99.83
CAS Nummer:
[415713-60-9]
Formel:
C14H11Cl3N2O3
Target-Kategorie:
RAD51
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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