JNJ-1013, CAS [[2597343-08-1]]

Produktübersicht

• Artikelname: JNJ-1013, CAS [[2597343-08-1]]
• Artikelnummer: MCE-HY-153188
• Hersteller Artikelnummer: HY-153188
• Alternativnummer: MCE-HY-153188-25MG,MCE-HY-153188-10MG,MCE-HY-153188-5MG,MCE-HY-153188-100MG,MCE-HY-153188-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBalpha, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834), black: linker (HY-Y1760), Blue: E3 ligase ligand (HY-112078))[1].

Produkteigenschaften

• Molekulargewicht: 878.05
• Reinheit: 99.97
• CAS Nummer: [2597343-08-1]
• Formel: C46H55N9O7S
• Target-Kategorie: Apoptosis,IRAK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound