SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity[1][2].
Molekulargewicht:
394.47
Reinheit:
99.96
CAS Nummer:
[1826116-38-4]
Formel:
C26H22N2O2
Target-Kategorie:
Apoptosis,MDM-2/p53
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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