MFH290 is a potent and highly selective cyclin-dependent kinase 12/13 (CDK12/13) covalent inhibitor. MFH290 forms a covalent bond with Cys-1039 of CDK12 and exhibits excellent kinome selectivity and inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II). MFH290 is used for cancer research[1].
Molekulargewicht:
525.69
Reinheit:
98.07
CAS Nummer:
[2088715-91-5]
Formel:
C26H31N5O3S2
Target-Kategorie:
CDK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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