Bexobrutideg, CAS [[2649400-34-8]]

Produktübersicht

• Artikelname: Bexobrutideg, CAS [[2649400-34-8]]
• Artikelnummer: MCE-HY-153321
• Hersteller Artikelnummer: HY-153321
• Alternativnummer: MCE-HY-153321-100MG,MCE-HY-153321-50MG,MCE-HY-153321-5MG,MCE-HY-153321-1MG,MCE-HY-153321-10MMX1ML,MCE-HY-153321-25MG,MCE-HY-153321-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: NX-5948, BTK-IN-24

Produktbeschreibung

Bexobrutideg (NX-5948) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. Bexobrutideg mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. Bexobrutideg is efficacious in a mouse collageninduced arthritis (CIA) model. Bexobrutideg can cross the blood brain barrier (BBB). Bexobrutideg is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: BTK ligand (HY-170324), Blue: CRBN ligand (HY-171893), Black: linker)[1][2][3].

Produkteigenschaften

• Molekulargewicht: 806.96
• Reinheit: 99.33
• CAS Nummer: [2649400-34-8]
• Formel: C42H54N12O5
• Target-Kategorie: Btk,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound