(R,R)-Bexobrutideg, CAS [[2649400-33-7]]

Produktübersicht

• Artikelname: (R,R)-Bexobrutideg, CAS [[2649400-33-7]]
• Artikelnummer: MCE-HY-153321A
• Hersteller Artikelnummer: HY-153321A
• Alternativnummer: MCE-HY-153321A-10MG,MCE-HY-153321A-50MG,MCE-HY-153321A-5MG,MCE-HY-153321A-100MG,MCE-HY-153321A-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (R,R)-NX-5948, (R,R)-BTK-IN-24

Produktbeschreibung

(R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324), Blue: CRBN ligand (HY-171893), Black: linker)[1][2][3].

Produkteigenschaften

• Molekulargewicht: 806.96
• Reinheit: 98.83
• CAS Nummer: [2649400-33-7]
• Formel: C42H54N12O5
• Target-Kategorie: Btk,Drug Isomer,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound