(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
Molekulargewicht:
383.44
Reinheit:
98.84
CAS Nummer:
[2935964-93-3]
Formel:
C20H18FN3O2S
Target-Kategorie:
HDAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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