MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]]

Produktübersicht

• Artikelname: MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]]
• Artikelnummer: MCE-HY-153360
• Hersteller Artikelnummer: HY-153360
• Alternativnummer: MCE-HY-153360-10MG,MCE-HY-153360-5MG,MCE-HY-153360-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].

Produkteigenschaften

• Molekulargewicht: 1038.04
• Reinheit: 98.99
• CAS Nummer: [2873460-70-7]
• Formel: C51H56FN9O14
• Target-Kategorie: Drug-Linker Conjugates for ADC,Topoisomerase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1