MK-2305 is an orally active GPR40 partial agonist with an EC50 of 6 nM in rats. MK-2305 mediates glucose-stimulated insulin secretion and inhibits endogenous glucose production by reducing gluconeogenesis from tricarboxylic acid (TCA) cycle substrates. MK-2305 increases plasma insulin levels under hyperglycemic and glucose-stimulated conditions, reduces fasting blood glucose, and improves glucose homeostasis. MK-2305 can be used in studies related to type 2 diabetes[1][2].
Molekulargewicht:
443.82
CAS Nummer:
[2101206-49-7]
Formel:
C19H13ClF3NO4S
Target-Kategorie:
Free Fatty Acid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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