ERK-CLIPTAC, CAS [[2087490-46-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: ERK-CLIPTAC, CAS [[2087490-46-6]] Preis auf Anfrage
• Artikelnummer: MCE-HY-153735
• Hersteller Artikelnummer: HY-153735
• Alternativnummer: MCE-HY-153735-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

ERK-CLIPTAC is a ERK CLIPTAC (click chemistry-synthesized proteolysis-targeting chimera) degrader. ERK-CLIPTAC forms intracellularly via click chemistry from ERK1/2-IN-14 (HY-175578) and Tz-thalidomide (HY-101460). The formed ERK-CLIPTAC recruits the E3 ubiquitin ligase CRBN to ERK1/2, thereby inducing ubiquitination and subsequent degradation of ERK1/2. Due to its lack of cell permeability, ERK-CLIPTAC cannot induce ERK1/2 degradation in cells. ERK-CLIPTAC can be used in research related to melanoma and colorectal cancer[1].

Produkteigenschaften

• Molekulargewicht: 1129.65
• CAS Nummer: [2087490-46-6]
• Formel: C60H61ClN12O9
• Target-Kategorie: ERK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound