FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 µM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].
Molekulargewicht:
362.36
Reinheit:
99.85
CAS Nummer:
[824983-90-6]
Formel:
C16H14N2O6S
Target-Kategorie:
FLAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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