TCRS-417, CAS [[2032123-28-5]]

Produktübersicht

• Artikelname: TCRS-417, CAS [[2032123-28-5]]
• Artikelnummer: MCE-HY-153916
• Hersteller Artikelnummer: HY-153916
• Alternativnummer: MCE-HY-153916-10MG,MCE-HY-153916-25MG,MCE-HY-153916-10MMX1ML,MCE-HY-153916-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: T417

Produktbeschreibung

TCRS-417 (T417) is a small-molecular inhibitor for PBX1. TCRS-417 can directly block PBX1-binding to DNA (IC50 = 6.58 µM), and affects PBX1 transcription. TCRS-417 is able to hammer out the stemness traits of Carboplatin (HY-17393)-resistant (CR) cells to revert to a differentiated status through tacking PBX1 signaling cascade. TCRS-417 significantly suppresses self-renewal and proliferation of cancer cells expressing high levels of PBX1. TCRS-417 can decrease the mRNA levels of FOXM1, NEK2, and E2F2 in cancer cell lines. TCRS-417 is selectively toxic against chr1q-amp myeloma and solid tumor cells[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 446.43
• Reinheit: 99.13
• CAS Nummer: [2032123-28-5]
• Formel: C25H19FN2O5
• Target-Kategorie: DNA/RNA Synthesis,HOXA,NEKs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound