20-Hydroxyvitamin D3, CAS [[651734-12-2]] Preis auf Anfrage
Artikelnummer:
MCE-HY-154825
Hersteller Artikelnummer:
HY-154825
Alternativnummer:
MCE-HY-154825-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
20(OH)D3, 20S-Hydroxyvitamin D3
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-kappaB activity via IkappaBalpha upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma[1][2][3][4].
