PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 µM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min)[1].
Molekulargewicht:
336.43
Reinheit:
99.25
Formel:
C21H24N2O2
Target-Kategorie:
Apoptosis,Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
