ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].
Molekulargewicht:
298.38
CAS Nummer:
[903639-13-4]
Formel:
C19H22O3
Target-Kategorie:
FLAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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