DDO-2728 (compound 19) is a selective AlkB homologue 5 (ALKBH5) inhibitor with an IC50 of 2.97 µM. DDO-2728 increases the abundance of N6 methyladenosine (m6A) modifications, inducing cell apoptosis and cycle arrest. DDO-2728 suppresses tumor growth in the MV4 11 xenograft model with favorable safety profile, shows the potential of targeting ALKBH5 in cancer research[1].
Molekulargewicht:
578.45
Reinheit:
98.55
CAS Nummer:
[3029515-97-4]
Formel:
C28H17F3N4O7
Target-Kategorie:
Anaplastic lymphoma kinase (ALK),Apoptosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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