AChE/Abeta-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 µM. AChE/Abeta-IN-1 also inhibits Abeta aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Abeta-IN-1 improves cognitive and spatial memory impairment in rats model[1].
Molekulargewicht:
401.34
Formel:
C20H25BrN4
Target-Kategorie:
Amyloid-beta,Cholinesterase (ChE),iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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