AChE/Abeta-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 µM. AChE/Abeta-IN-2 also inhibits Abeta aggregation and shows good blood-brain barrier permeability. AChE/Abeta-IN-2 improves cognitive and spatial memory impairment in rats model[1].
Molekulargewicht:
356.89
Formel:
C20H25ClN4
Target-Kategorie:
Amyloid-beta,Cholinesterase (ChE),iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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