STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 µM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 µM and 3.26 µM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
Molekulargewicht:
593.64
Reinheit:
99.83
CAS Nummer:
[2768427-54-7]
Formel:
C30H27F4N7S
Target-Kategorie:
STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
