HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].
Molekulargewicht:
428.53
Reinheit:
99.11
CAS Nummer:
[1066676-21-8]
Formel:
C26H28N4O2
Target-Kategorie:
Hydroxycarboxylic Acid Receptor (HCAR)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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