CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM, 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37µM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1].
Molekulargewicht:
440.97
CAS Nummer:
[1256963-02-6]
Formel:
C22H29ClN8
Target-Kategorie:
CDK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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