IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML)[1].
Molekulargewicht:
484.40
CAS Nummer:
[2749568-16-7]
Formel:
C21H18F6N6O
Target-Kategorie:
Isocitrate Dehydrogenase (IDH)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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