GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 µM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 µM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1][2][3].
Molekulargewicht:
453.96
Reinheit:
99.01
CAS Nummer:
[1797983-09-5]
Formel:
C24H28ClN5O2
Target-Kategorie:
Histone Demethylase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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