Senexin A is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-kappaB-dependent promoters[1][2].
Molekulargewicht:
274.32
Reinheit:
99.79
CAS Nummer:
[1366002-50-7]
Formel:
C17H14N4
Target-Kategorie:
CDK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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