NODAGA-NHS (NODA-GA-NHS ester) is the activated ester form of the NODAGA chelator. NODAGA-NHS conjugates with Trastuzumab (HY-P9907) to form NODAGA-Trastuzumab, a conjugate that can chelate 64Cu for the preparation of radiotracers. NODAGA-NHS covalently binds to the amino group of lactosamine derivatives to form radiotracer precursors. [64Cu]NODAGA-trastuzumab enables PET imaging of tumors expressing HER2. NODAGA-NHS is used in studies of HER2-positive breast cancer and ovarian adenocarcinoma[1][2].
Molekulargewicht:
472.45
CAS Nummer:
[1407166-70-4]
Formel:
C19H28N4O10
Target-Kategorie:
EGFR,Radionuclide-Drug Conjugates (RDCs)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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