Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 µM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling[1][2][3].
Molekulargewicht:
421.49
Reinheit:
98
CAS Nummer:
[344897-95-6]
Formel:
C22H15NO4S2
Target-Kategorie:
Complement System,Integrin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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