ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 µM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 µM (1*Km SAM) and 2.3 µM (10*Km SAM), respectively[1].
Molekulargewicht:
491.62
CAS Nummer:
[337486-54-1]
Formel:
C30H37NO5
Target-Kategorie:
ICMT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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