Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 µM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].
Molekulargewicht:
308.30
Formel:
C19H13FO3
Target-Kategorie:
Microtubule/Tubulin,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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