STX-721, CAS [[2765525-82-2]]

Produktübersicht

• Artikelname: STX-721, CAS [[2765525-82-2]]
• Artikelnummer: MCE-HY-157229
• Hersteller Artikelnummer: HY-157229
• Alternativnummer: MCE-HY-157229-5MG,MCE-HY-157229-10MG,MCE-HY-157229-10MMX1ML,MCE-HY-157229-100MG,MCE-HY-157229-25MG,MCE-HY-157229-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

STX-721 is an orally active, irreversible, covalent EGFR exon 20 insertion (ex20ins) inhibitor that selectively targets ex20ins-mutant dynamic protein states. STX-721 potently inhibits the kinase activity of EGFR ex20ins mutants (NPG, ASV, SVD). STX-721 inhibits phosphorylation of EGFR (pEGFR Y1068) and downstream ERK (pERK Thr202/Tyr204), and suppresses proliferation of ex20ins-mutant Ba/F3 cells and human NSCLC cell lines (NCI-H2073 ASV KI, CUTO-14 ASV). STX-721 induces tumor regression in EGFR ex20ins-mutant PDX/CDX models. STX-721 can be used for the study of non-small cell lung cancer (NSCLC) harboring EGFR or HER2 ex20ins mutations[1][2].

Produkteigenschaften

• Molekulargewicht: 587.11
• Reinheit: 98.25
• CAS Nummer: [2765525-82-2]
• Formel: C32H35ClN6O3
• Target-Kategorie: EGFR,ERK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound