Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 (Compound 3) is a linker-payload component of an antibody-drug conjugate (ADC). Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 selectively delivers the dual-function BTK degrader to B-cell malignancies by targeting the monoclonal antibody of CD79b. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 can be coupled to the engineered CD79b antibody with cysteine, forming CD79b-3 ADC (ADC linker: (HY-130944), Protac: (HY-163295)).
Molekulargewicht:
1671.63
Formel:
C80H94F2N14O20P2
Target-Kategorie:
PROTAC-Linker Conjugates for PAC,Transmembrane Glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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