LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research[1].
Molekulargewicht:
467.44
Reinheit:
98.83
CAS Nummer:
[2834106-06-6]
Formel:
C21H17F4N3O3S
Target-Kategorie:
Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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