AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 µM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA[1].
Molekulargewicht:
332.35
Formel:
C20H16N2O3
Target-Kategorie:
Aurora Kinase,Mitosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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