NF-kappaB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-kappaB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-kappaB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-kappaB-IN-16 potently inhibits the NF-kappaB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-kappaB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models[1].
Molekulargewicht:
837.01
Formel:
C26H35Cl3N2O10Pt
Target-Kategorie:
Apoptosis,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
