SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 µM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1].
Molekulargewicht:
410.40
CAS Nummer:
[124623-00-3]
Formel:
C22H19FN2O5
Target-Kategorie:
Topoisomerase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
