PI3Kdelta-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases delta (PI3Kdelta), with an IC50 of 13.6 nM. PI3Kdelta-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kdelta-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model[1].
Molekulargewicht:
405.84
Formel:
C19H16ClN9
Target-Kategorie:
PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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