CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model[1].
Molekulargewicht:
466.53
Formel:
C24H30N6O4
Target-Kategorie:
Cytochrome P450,Fungal
Anwendungsbeschreibung:
MCE Product type: Reference compound
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