Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity[1].
Molekulargewicht:
990.62
Formel:
C55H61ClFN5O7S
Target-Kategorie:
Bcl-2 Family
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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