VVD-130037, CAS [[3034880-93-5]]

Produktübersicht

• Artikelname: VVD-130037, CAS [[3034880-93-5]]
• Artikelnummer: MCE-HY-159641
• Hersteller Artikelnummer: HY-159641
• Alternativnummer: MCE-HY-159641-5MG,MCE-HY-159641-10MG,MCE-HY-159641-25MG,MCE-HY-159641-50MG,MCE-HY-159641-100MG,MCE-HY-159641-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: BAY-3605349

Produktbeschreibung

VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 344.80
• Reinheit: 99.91
• CAS Nummer: [3034880-93-5]
• Formel: C17H17ClN4O2
• Target-Kategorie: Keap1-Nrf2,Molecular Glues

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1