GNF179 (Metabolite), CAS [[1310455-86-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: GNF179 (Metabolite), CAS [[1310455-86-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-15980
• Hersteller Artikelnummer: HY-15980
• Alternativnummer: MCE-HY-15980-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. IC50 value: Target: Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.

Produkteigenschaften

• Molekulargewicht: 245.30
• CAS Nummer: [1310455-86-7]
• Formel: C14H16FN3
• Target-Kategorie: Parasite

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound