PAR4 antagonist 8 (Compound 20f) is an effective, orally active, and selective PAR4 antagonist with an IC50 value of 15.32 nM. PAR4 antagonist 8 exhibits favorable pharmacokinetic properties. PAR4 antagonist 8 not only effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50 = 6.39 nM) but also inhibits mouse platelet aggregation. PAR4 antagonist 8 can be used in antithrombotic research[1].
Molekulargewicht:
559.54
Formel:
C28H19F2N5O4S
Target-Kategorie:
Protease Activated Receptor (PAR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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