CS4 is a selective HDAC inhibitor with the IC50 values of 38 nM, 12 nM, 5.8 µM, 19 µM and 61 µM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes alpha-tubulin and histone 3 acetylation. CS4 activates PPARgamma and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro[1].
Molekulargewicht:
288.34
Formel:
C16H20N2O3
Target-Kategorie:
Apoptosis,HDAC,PPAR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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