Elisrasib (D3S-001) is an orally active and selective inhibitor for KRAS. Elisrasib inhibits the proliferation of KRASG12C mutant H358 and MIA-PA-CA-2. D3S-001 also inhibits the phosphorylation of cellular ERK1/2. Elisrasib exhibits good metabolic stability in hepatocytes, liver microsomes, plasma and whole blood in various species. D3S-001 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice[1].
Molekulargewicht:
679.66
Reinheit:
98.50
CAS Nummer:
[2914919-85-8]
Formel:
C32H35F6N7O3
Target-Kategorie:
PERK,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
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